Open AccessTarget Of Rapamycin pathway in the white-rot fungus Phanerochaete chrysosporium
Author(s) -
Duy Vuong Nguyen,
Thomas Roret,
Antonio José Fernández-González,
Annegret Kohler,
Mélanie MorelRouhier,
Éric Gelhaye,
Rodnay Sormani
Publication year - 2020
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0224776
Subject(s) - chrysosporium , phanerochaete , tor signaling , fungus , biology , hypha , pathogenic fungus , microbiology and biotechnology , signal transduction , botany , lignin
The Target Of Rapamycin (TOR) signaling pathway is known to regulate growth in response to nutrient availability and stress in eukaryotic cells. In the present study, we have investigated the TOR pathway in the white-rot fungus Phanerochaete chrysosporium . Inhibition of TOR activity by rapamycin affects conidia germination and hyphal growth highlighting the conserved mechanism of susceptibility to rapamycin. Interestingly, the secreted protein content is also affected by the rapamycin treatment. Finally, homologs of the components of TOR pathway can be identified in P . chrysosporium . Altogether, those results indicate that the TOR pathway of P . chrysosporium plays a central role in this fungus.