Open AccessThe effectiveness of interferon beta versus glatiramer acetate and natalizumab versus fingolimod in a Polish real-world population
Author(s) -
Katarzyna Kapica-Topczewska,
Joanna Tarasiuk,
François Collin,
Waldemar Brola,
Monika Chorąży,
Agata Czarnowska,
Mirosław Kwaśniewski,
Halina Bartosik-Psujek,
Monika Adamczyk-Sowa,
Jan Kochanowicz,
Alina Kułakowska
Publication year - 2019
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0223863
Subject(s) - fingolimod , natalizumab , glatiramer acetate , multiple sclerosis , interferon beta , medicine , interferon beta 1a , population , pharmacology , virology , immunology , environmental health
Objective The aim of the study was to assess the effectiveness of disease-modifying therapies (DMTs) in relapsing-remitting multiple sclerosis (RRMS) patients treated in MS centres in Poland. Methods Demographic and clinical data of all Polish RRMS patients receiving DMTs were prospectively collected from 2014 to 2018 in electronic files using the Therapeutic Program Monitoring System (SMPT). Results The study included 10,764 RRMS patients treated with DMTs in first-line and 1,042 in second-line programmes. IFNβ more effectively lengthened the times to the first relapse, disability progression, and brain MRI activity than GA. After 2 and 4 years of follow-up, more patients on IFNβ showed no evidence of disease activity (NEDA-3) in comparison to GA (66.3% and 44.3% vs 55.2% and 33.2%, respectively; p<0.001). NAT more effectively reduced brain MRI activity than FTY (p = 0.001). More patients under NAT had NEDA-3 after 2 and 4 years of follow-up compared to FTY (66.2% and 42.1% vs 52.1% and 29.5%, respectively; p = 0.03). In adjusted analysis, a higher baseline Expanded Disability Status Score (EDSS) was a predictor of relapse (p<0.001) and NEDA-3 failure (p = 0.003). Conclusion IFNβ compared to GA and NAT compared to FTY more effectively reduced disease activity in a Polish population of RRMS patients.