Open AccessProtective effect of Platymiscium floribundum Vog. in tree extract on periodontitis inflammation in rats
Author(s) -
Jordânia M. O. Freire,
Hellíada Vasconcelos Chaves,
Alrieta Henrique Teixeira,
Luzia Hermínia Teixeira Sousa,
Isabela Ribeiro Pinto,
José Jackson do N. Costa,
Nayara Alves de Sousa,
Karuza Maria Alves Pereira,
Virgínia Cláudia Carneiro Girão-Carmona,
Vanessa C. S. Ferreira,
João Evangelista de Ávila dos Santos,
Mary Anne Sousa Lima,
Antônia Torres Ávila Pimenta,
Raquel de C. Montenegro,
Maria Elisabete Amaral de Moraes,
Vicente de Paulo Teixeira Pinto,
Gerardo Cristino Filho,
Mirna Marques Bezerra
Publication year - 2019
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0223800
Subject(s) - periodontitis , medicine , inflammation , dentistry
Periodontitis is an immuno-inflammatory disease, which can lead to tooth loss. This study aimed to investigate the efficacy of Platymiscium floribundum Vog., a Brazilian tree which has been used in folk medicine as an anti-inflammatory agent, in a pre-clinical trial of periodontitis in rats. Periodontitis was induced by placing a sterilized nylon (3.0) thread ligature around the cervix of the second left upper molar of the rats, which received ( per os ) P . floribundum extract (0.1, 1 or 10 mg/kg) or vehicle 1h before periodontitis-challenge and once daily during 11 days. Treatment with P . floribundum (10mg/kg) decreased alveolar bone loss, MPO activity nitrite/nitrate levels, oxidative stress, TNF-α, IL1-β, IL-8/CINC-1, and PGE2 gingival levels, and transcription of TNF-α, IL1-β, COX-2, iNOS, RANK, and RANKL genes, while elevated both BALP serum levels and IL-10 gingival levels. The animals did not show signs of toxicity throughout the experimental course. These findings show that P . floribundum has anti-inflammatory and anti-resorptive properties in a pre-clinical trial of periodontitis, representing an interesting biotechnological tool.