Open AccessEffects of dietary intake and nutritional status on cerebral oxygenation in patients with chronic kidney disease not undergoing dialysis: A cross-sectional study
Author(s) -
Susumu Ookawara,
Yoshio Kaku,
Ito K,
Kanako Kizukuri,
Aiko Namikawa,
Shinobu Nakahara,
Yuko Horiuchi,
Nagisa Inose,
Mayako Miyahara,
Michiko Shiina,
Saori Minato,
Mitsutoshi Shindo,
Haruhisa Miyazawa,
Keiji Hirai,
Taro Hoshino,
Miho Murakoshi,
Kaoru Tabei,
Yoshiyuki Morishita
Publication year - 2019
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0223605
Subject(s) - medicine , renal function , kidney disease , body mass index , dialysis , endocrinology
Background Dietary management is highly important for the maintenance of renal function in patients with chronic kidney disease (CKD). Cerebral oxygen saturation (rSO 2 ) was reportedly associated with the estimated glomerular filtration rate (eGFR) and cognitive function. However, data concerning the association between cerebral rSO 2 and dietary intake of CKD patients is limited. Methods This was a single-center observational study. We recruited 67 CKD patients not undergoing dialysis. Cerebral rSO 2 was monitored using the INVOS 5100c oxygen saturation monitor. Energy intake was evaluated by dietitians based on 3-day meal records. Daily protein and salt intakes were calculated from 24-h urine collection. Results Multivariable regression analysis showed that cerebral rSO 2 was independently associated with energy intake (standardized coefficient: 0.370) and serum albumin concentration (standardized coefficient: 0.236) in Model 1 using parameters with p < 0.10 in simple linear regression analysis (body mass index, Hb level, serum albumin concentration, salt and energy intake) and confounding factors (eGFR, serum sodium concentration, protein intake), and the energy/salt index (standardized coefficient: 0.343) and Hb level (standardized coefficient: 0.284) in Model 2 using energy/protein index as indicated by energy intake/protein intake and energy/salt index by energy intake/salt intake in place of salt, protein and energy intake. Conclusions Cerebral rSO 2 is affected by energy intake, energy/salt index, serum albumin concentration and Hb level. Sufficient energy intake and adequate salt restriction is important to prevent deterioration of cerebral oxygenation, which might contribute to the maintenance of cognitive function in addition to the prevention of renal dysfunction in CKD patients.