Open AccessSerum E-selectin concentration is associated with risk of metabolic syndrome in females
Author(s) -
Chien-Hsing Lee,
Feng-Chih Kuo,
Wenhao Tang,
Chieh-Hua Lu,
Sheng-Chiang Su,
JhihSyuan Liu,
ChangHsun Hsieh,
YiJen Hung,
Fu-Huang Lin
Publication year - 2019
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0222815
Subject(s) - metabolic syndrome , medicine , anthropometry , body mass index , waist , blood pressure , endocrinology , endothelial dysfunction , obesity
Objectives Traits of metabolic syndrome (MetS) and biomarkers of inflammation and endothelial dysfunction were examined. We investigated the differences of various biomarkers among individuals with or without Mets in a gender-specific manner. The gender-specific associations between E-selectin and MetS were further evaluated. Methods A total of 205 patients were recruited from the outpatient clinics of Tri-Service General Hospital, Taipei, Taiwan. Inclusion criteria were age between 20–75 years and BMI < 35 kg/m 2 . Demographic, anthropometric and MetS index data were compared between genders. Markers of inflammation and endothelial dysfunction were compared between individuals with or without MetS by gender. Results Age-adjusted E-selectin values showed significant positive correlations with BMI, waist-hip ratio, fasting plasma glucose, systolic and diastolic blood pressure, triglycerides, TNF-α, hsCRP and ICAM-1, and inverse correlation with HDL cholesterol. E-selectin levels were positively correlated with numbers of MetS components in females (P < 0.001) but not in males (P = 0.125). Conclusions Increased E-selectin levels are significantly associated with increased MetS risk in females, but not in males.