Normal B cell development and Pax5 expression in Thy28/ThyN1-deficient mice | Zendy

Fusako Kitaura | Zendy; Miyuki Yuno | Zendy; Toshitsugu Fujita | Zendy; Shigeharu Wakana | Zendy; Jun Ueda | Zendy; Kazuo Yamagata | Zendy; Hodaka Fujii | Zendy

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Normal B cell development and Pax5 expression in Thy28/ThyN1-deficient mice

Author(s) -

Fusako Kitaura,

Miyuki Yuno,

Toshitsugu Fujita,

Shigeharu Wakana,

Jun Ueda,

Kazuo Yamagata,

Hodaka Fujii

Publication year - 2019

Publication title -

plos one

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.99

H-Index - 332

ISSN - 1932-6203

DOI - 10.1371/journal.pone.0220199

Subject(s) - pax5 , transcription factor , biology , b cell , microbiology and biotechnology , cell culture , gene , gene expression , cell , regulation of gene expression , genetics , antibody

Thy28, also known as ThyN1, is a highly conserved nuclear protein. We previously showed that in a chicken mature B cell line, Thy28 binds to the promoter of the gene encoding Pax5 , a transcription factor essential for B cell development, and positively regulates its expression. Here, we generated a Thy28 -deficient mouse line to analyze its potential role in B cell development in mice. Thy28 -deficient mice showed normal development of B cells, and the expression of Pax5 was comparable between wild-type and Thy28 -deficient primary B cells. Thus, species-specific mechanisms regulate Pax5 expression and B cell development.

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