Open AccessDevelopment and validation of quick Acute Kidney Injury-score (q-AKI) to predict acute kidney injury at admission to a multidisciplinary intensive care unit
Author(s) -
Fiorenza Ferrari,
Mariangela Valentina Puci,
Ottavia Eleonora Ferraro,
Gregorio RomeroGonzález,
Faeq HusainSyed,
Lilia Rizo-Topete,
Mara Senzolo,
Anna Lorenzin,
Eva Muraro,
Antonio Baracca,
Mara Serrano-Soto,
Alejandra Molano-Triviño,
Ana Castro,
Massimo de Cal,
Valentina Corradi,
Alessandra Brendolan,
Marta Scarpa,
M. Carta,
Davide Giavarina,
Raffaele Bonato,
Giorgio Iotti,
Claudio Ronco
Publication year - 2019
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0217424
Subject(s) - acute kidney injury , medicine , kidney disease , intensive care unit , severity of illness , retrospective cohort study , intensive care medicine
AKI is associated with increased risk of death, prolonged length of stay and development of de-novo chronic kidney disease. The aim of our study is the development and validation of prediction models to identify the risk of AKI in ICU patients up to 7 days. We retrospectively recruited 692 consecutive patients admitted to the ICU at San Bortolo Hospital (Vicenza, Italy) from 1 June 2016 to 31 March 2017: 455 patients were treated as the derivation group and 237 as the validation group. Candidate variables were selected based on a literature review and expert opinion. Admission eGFR< 90 ml/min /1.73 mq (OR 2.78; 95% CI 1.78–4.35; p<0.001); SOFAcv ≥ 2 (OR 2.23; 95% CI 1.48–3.37; p<0.001); lactate ≥ 2 mmol/L (OR 1.81; 95% CI 1.19–2.74; p = 0.005) and (TIMP-2)•(IGFBP7) ≥ 0.3 (OR 1.65; 95% CI 1.08–2.52; p = 0.019) were significantly associated with AKI. For the q-AKI score, we stratified patients into different AKI Risk score levels: 0–2; 3–4; 5–6; 7–8 and 9–10. In both cohorts, we observed that the proportion of AKI patients was higher in the higher score levels.