Open AccessAssessment of lung function in successfully treated tuberculosis reveals high burden of ventilatory defects and COPD
Author(s) -
Akshay Gupte,
Mandar Paradkar,
Sriram Selvaraju,
Kannan Thiruvengadam,
Shri Vijay Bala Yogendra Shivakumar,
Krithikaa Sekar,
Srinivasa Marinaik,
Ayesha Momin,
Archana Vijay Gaikwad,
Premkumar Natrajan,
Munivardhan Prithivi,
Gomathy Shivaramakrishnan,
Neeta Pradhan,
Rewa Kohli,
Swapnil Raskar,
Deepali Jain,
Rani Velu,
Bharath Karthavarayan,
Rahul Lokhande,
Nishi Suryavanshi,
Nikhil Gupte,
Lakshmi Murali,
Sundeep Salvi,
William Checkley,
Jonathan E. Golub,
Robert C. Bollinger,
Vidya Mave,
Prabha Chandrasekaran,
Amita Gupta
Publication year - 2019
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0217289
Subject(s) - medicine , spirometry , copd , bronchodilator , body mass index , pulmonary function testing , cardiology , asthma
Background Burden, phenotype and risk-factors of lung function defects in successfully treated tuberculosis cases are unclear. Methods We performed spirometry with bronchodilators in new drug-sensitive adult (≥18 years) pulmonary tuberculosis cases during the 12 months following successful treatment in India. Airflow obstruction was defined as pre-bronchodilator FEV1/FVC<5 th percentile of Global Lung Initiative mixed-ethnicity reference (lower limit of normal [LLN]). Chronic obstructive pulmonary disease (COPD) was defined as post-bronchodilator FEV1/FVC