Open AccessZnO-NPs embedded biodegradable thiolated bandage for postoperative surgical site infection: In vitro and in vivo evaluation
Author(s) -
Rabia Arshad,
Muhammad Sohail,
Hafiz Shoaib Sarwar,
Hamid Saeed,
Ali Imran,
Sohail Akhtar,
Syed Zajif Hussain,
Iqra Afzal,
Sarwat Jahan,
Anees Ur Rehman,
Gul Shahnaz
Publication year - 2019
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0217079
Subject(s) - bandage , in vivo , wound healing , medicine , chitosan , mucoadhesion , surgical wound , surgery , pharmacology , drug , chemistry , drug carrier , microbiology and biotechnology , biochemistry , biology
Post-operative surgical site infections (SSI) present a serious threat and may lead to complications. Currently available dressings for SSI lack mucoadhesion, safety, efficacy and most importantly patient compliance. We aimed to address these concerns by developing a bioactive thiolated chitosan-alginate bandage embedded with zinc oxide nanoparticles (ZnO-NPs) for localized topical treatment of SSI. The FTIR, XRD, DSC and TGA of bandage confirmed the compatibility of ingredients and modifications made. The porosity, swelling index and lysozyme degradation showed good properties for wound healing and biodegradation. Moreover, in-vitro antibacterial activity showed higher bactericidal effect as compared to ZnO-NPs free bandage. In-vivo wound healing in murine model showed significant improved tissue generation and speedy wound healing as compared to positive and negative controls. Over all, thiolated bandage showed potential as an advanced therapeutic agent for treating surgical site infections, meeting the required features of an ideal surgical dressing.