Open AccessVascular maturity of type 1 and type 2 choroidal neovascularization evaluated by optical coherence tomography angiography
Author(s) -
Yuyako Nakano,
Keiko Kataoka,
Jun Takeuchi,
Ai Fujita,
Hiroki Kaneko,
Hideyuki Shimizu,
Yasuki Ito,
Hiroko Terasaki
Publication year - 2019
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0216304
Subject(s) - choroidal neovascularization , optical coherence tomography angiography , ophthalmology , copy number variation , macular degeneration , optical coherence tomography , medicine , angiography , biology , radiology , genetics , gene , genome
Purpose Vessel maturation is considered to proceed by pruning branches resulting in less branching vessels. This study investigated the vessel junction densities of type 1 and type 2 choroidal neovascularizations (CNVs) using optical coherence tomography angiography (OCTA). Methods We collected consecutive data from treatment-naïve eyes diagnosed with typical age-related macular degeneration (AMD). The OCTA images with CNV were analyzed to calculate vessel areas, vessel lengths, and vessel junction densities. Results Of 60 eyes in 60 patients, type 1 CNV diagnoses had been made in 40 eyes, and type 2 CNV in 20 eyes. We found no significant difference in vessel areas between type 1 CNV and type 2 CNV (type 1 CNV, 0.44 ± 0.37 mm 2 ; type 2 CNV, 0.37 ± 0.48 mm 2 ), and no significant difference in vessel lengths (type 1 CNV, 18.24 ± 15.96 mm; type 2 CNV, 16.13 ± 21.45 mm). However, the vessel junction density of type 1 CNV was significantly lower than that of type 2 CNV by 16.0% (P = 0.008). Conclusion OCTA revealed that the vessel junction densities of type 1 CNVs were lower than those of type 2 CNVs, suggesting type 1 CNV vessels are more mature than type 2 CNV vessels.