Open AccessNegative BOLD responses during hand and foot movements: An fMRI study
Author(s) -
Hiroki Nakata,
Ryo Domoto,
Nobuaki Mizuguchi,
Kiwako Sakamoto,
Kazuyuki Kanosue
Publication year - 2019
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0215736
Subject(s) - medial frontal gyrus , precuneus , superior frontal gyrus , middle frontal gyrus , middle temporal gyrus , functional magnetic resonance imaging , limbic lobe , neuroscience , supramarginal gyrus , parahippocampal gyrus , supplementary motor area , gyrus , psychology , precentral gyrus , lingual gyrus , medicine , magnetic resonance imaging , temporal lobe , radiology , epilepsy
The present study employed functional magnetic resonance imaging (fMRI) to examine the characteristics of negative blood oxygen level-dependent (Negative BOLD) signals during motor execution. Subjects repeated extension and flexion of one of the following: the right hand, left hand, right ankle, or left ankle. Negative BOLD responses during hand movements were observed in the ipsilateral hemisphere of the hand primary sensorimotor area (SMI), medial frontal gyrus (MeFG), middle frontal gyrus (MFG), and superior frontal gyrus (SFG). Negative BOLD responses during foot movements were also noted in the bilateral hand SMI, MeFG, MFG, SFG, inferior frontal gyrus, middle temporal gyrus, parahippocampal gyrus, anterior cingulate cortex, cingulate gyrus (CG), fusiform gyrus, and precuneus. A conjunction analysis showed that portions of the MeFG and CG involving similar regions to those of the default mode network were commonly deactivated during voluntary movements of the right/left hand or foot. The present results suggest that three mechanisms are involved in the Negative BOLD responses observed during voluntary movements: (1) transcallosal inhibition from the contralateral to ipsilateral hemisphere in the SMI, (2) the deactivated neural network with several brain regions, and (3) the default mode network in the MeFG and CG.