Open AccessAmino acids disrupt calcium-dependent adhesion of stratum corneum
Author(s) -
Jin-Hyun Kim,
Byoung Jun Ahn,
Sung-Woo Choi,
Sohyun In,
A. Reum Goh,
Sun-Gyoo Park,
Cheon-Koo Lee,
Nam Lyong Kang
Publication year - 2019
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0215244
Subject(s) - stratum corneum , amino acid , chelation , biophysics , calcium , chemistry , exfoliation joint , adhesion , biochemistry , microbiology and biotechnology , biology , materials science , nanotechnology , organic chemistry , genetics , graphene
In the stratum corneum, the intercellular junction made up of cadherin proteins provides the structural integrity of the framework. Ca 2+ ions are known to play a key role in maintaining this junction. In this study, we hypothesized that Ca 2+ chelation in stratum corneum will weaken the bond of the tissue and consequently promote exfoliation. Amino acids, ubiquitously existing as metabolites and building blocks of the body, have the molecular property to chelate Ca 2+ ions. In the current study, we verified the Ca 2+ chelating property of amino acids and demonstrated that amino acids can interfere with the interaction of cadherins, separate stratum corneum into pieces, and thereby stimulate the exfoliation process of skin. These results validate the importance of Ca 2+ ion in the skin exfoliation process. Importantly, our findings indicate that amino acids may be efficiently used for improving skin conditions.