Open AccessDecreased orbital fat and enophthalmos due to bimatoprost: Quantitative analysis using magnetic resonance imaging
Author(s) -
Tomoaki Higashiyama,
Takayuki Minamikawa,
Masashi Kakinoki,
Osamu Sawada,
Masahito Ohji
Publication year - 2019
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0214065
Subject(s) - enophthalmos , bimatoprost , magnetic resonance imaging , extraocular muscles , medicine , ophthalmology , nuclear medicine , glaucoma , ocular hypertension , radiology , diplopia
We quantitatively determined the relation between the decrease in orbital fat and enophthalmos due to bimatoprost using magnetic resonance imaging (MRI). Nine orbits in nine patients were treated unilaterally with bimatoprost for glaucoma or ocular hypertension. The contralateral orbits were used as controls. The volumes of the orbital tissues and the enophthalmos were measured using MRI. The mean volumes on the treated and untreated sides were, respectively, 14.6 ± 2.1 and 17.0 ± 4.3 cm 3 for orbital fat ( P = 0.04) and 3.4 ± 0.5 and 3.3 ± 0.5 cm 3 for total extraocular muscles ( P = 0.85). The mean enophthalmos values were 14.7 ± 2.5 and 16.0 ± 2.3 mm on the treated and untreated sides, respectively ( P = 0.002). The data acquired by quantitatively measuring the volumes of orbital fat and enophthalmos on MRI showed that each might be reduced by bimatoprost administration. The enophthalmos could be caused by the bimatoprost-induced decrease in orbital fat.