Open AccessThe role of the erythrocyte in the outcome of pregnancy with preeclampsia
Author(s) -
Márcia Aires Rodrigues de Freitas,
Alice Vieira da Costa,
Luciana Alves de Medeiros,
Lucas Moreira Cunha,
Ubirajara Coutinho Filho,
Mário da Silva Garrote-Filho,
Angélica Lemos Debs Diniz,
Nilson PenhaSilva
Publication year - 2019
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0212763
Subject(s) - preeclampsia , hemodynamics , microcytosis , medicine , gestational age , pregnancy , hemoglobin , population , anthropometry , hematocrit , physiology , anemia , gastroenterology , cardiology , endocrinology , biology , iron deficiency , genetics , environmental health
The objective of this study was to analyze the relationships of osmotic and mechanical stability of erythrocytes with anthropometric, biochemical, hematologic and hemodynamic variables in pregnant women with preeclampsia (PE). The studied population consisted of 20 normotensive patients and 16 patients with PE. Patients with PE presented worse gestational outcome, greater hematologic impairment, erythrocytes osmotically more stable in vitro , but in conditions of isotonicity with the in vivo medium, in addition to hyperflow in orbital territory, when compared to normotensive patients. The correlation analysis between anthropometric, hematologic and hemodynamic variables in patients with PE indicated that erythrocytes with lower volumes and lower levels of hemoglobin favor the occurrence of a better gestational outcome, because they are more stable and because they are associated with a decrease in the hemodynamic changes present in the disease. This should mean that the tendency to microcytosis, probably due to a mechanism of compensatory mechanical selection, is a desirable characteristic in the disease.