Open AccessInjectable polypeptide hydrogel/inorganic nanoparticle composites for bone tissue engineering
Author(s) -
Wei-Shun Huang,
IMing Chu
Publication year - 2019
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0210285
Subject(s) - self healing hydrogels , nanoparticle , scaffold , tissue engineering , materials science , biomedical engineering , biocompatible material , biocompatibility , magnetic nanoparticles , polyethylene glycol , copolymer , nanotechnology , chemistry , composite material , polymer , polymer chemistry , medicine , organic chemistry , metallurgy
The general concept of tissue engineering is to restore biological function by replacing defective tissues with implantable, biocompatible, and easily handleable cell-laden scaffolds. In this study, osteoinductive and osteoconductive super paramagnetic Fe 3 O 4 nanoparticles (MNP) and hydroxyapatite (HAP) nanoparticles were incorporated into a di-block copolymer based thermo-responsive hydrogel, methoxy(polyethylene glycol)-polyalanine (mPA), at various concentrations to afford composite, injectable hydrogels. Incorporating nanoparticles into the thermo-responsive hydrogel increased the complex viscosity and decreased the gelation temperature of the starting hydrogel. Functionally, the integration of inorganic nanoparticles modulated bio-markers of bone differentiation and enhanced bone mineralization. Moreover, this study adopted the emerging method of using either a supplementary static magnetic field (SMF) or a moving magnetic field to elicit biological response. These results demonstrate that combining external (magnet) and internal (scaffold) magnetisms is a promising approach for bone regeneration.