Open AccessLimited detection of human polyomaviruses in Fanconi anemia related squamous cell carcinoma
Author(s) -
Tuna Toptan,
Marion G. Brusadelli,
Brian Turpin,
David P. Witte,
Jordi Surrallés,
Eunike Velleuer,
Martin Schramm,
Ralf Dietrich,
Ruud H. Brakenhoff,
Patrick S. Moore,
Yuan Chang,
Susanne I. Wells
Publication year - 2018
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0209235
Subject(s) - fanconi anemia , head and neck squamous cell carcinoma , head and neck cancer , population , immunohistochemistry , epidermoid carcinoma , cancer , cancer research , pathology , biology , medicine , carcinoma , dna repair , gene , genetics , environmental health
Fanconi anemia is a rare genome instability disorder with extreme susceptibility to squamous cell carcinoma of the head and neck and anogenital tract. In patients with this inherited disorder, the risk of head and neck cancer is 800-fold higher than in the general population, a finding which might suggest a viral etiology. Here, we analyzed the possible contribution of human polyomaviruses to FA-associated head and neck squamous cell carcinoma (HNSCC) by a pan-polyomavirus immunohistochemistry test which detects the T antigens of all known human polyomaviruses. We observed weak reactivity in 17% of the HNSCC samples suggesting that based on classical criteria, human polyomaviruses are not causally related to squamous cell carcinomas analyzed in this study.