Open AccessMetabolic risk factors in young adults infected with HIV since childhood compared with the general population
Author(s) -
Élise Arrivé,
JeanPaul Viard,
Benoît Salanave,
Catherine Dollfus,
Sophie Matheron,
Véronique Reliquet,
Elisa Arezes,
Laura Nailler,
Corinne Vigouroux,
Josiane Warszawski,
Enns study groups
Publication year - 2018
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0206745
Subject(s) - medicine , body mass index , waist , metabolic syndrome , population , overweight , dyslipidemia , cross sectional study , cohort , national cholesterol education program , young adult , odds ratio , cohort study , national health and nutrition examination survey , obesity , environmental health , pathology
Aim Metabolic risk factors are poorly documented for the first generation of young adults who have lived with HIV since childhood. We compared their metabolic profile with that of adults of same age from the general population. Methods We conducted a cross-sectional analysis of data from two populations: (1) COVERTE (ANRS-CO19), a French national cohort of 18 to 30-year-old patients HIV-infected since childhood, and (2) ENNS, a national cross-sectional population-based household survey on nutrition. Body mass index (BMI), blood pressure, waist circumference, fasting glucose, triglycerides, and HDL-, LDL- and total cholesterol were measured in both studies. Direct standardization on overweight and education level and logistic regression were used to compare the prevalence of metabolic abnormalities between the two populations. Results Data from 268 patients from COVERTE and 245 subjects from ENNS were analyzed. Tobacco use was similar in both groups. HIV-infected patients had increased mean waist-to-hip ratio and triglycerides to HDL-cholesterol ratio and decreased mean HDL-cholesterol as compared to their counterparts from the general population in both genders. In HIV-infected patients, metabolic syndrome was identified in 13.2% of men (95% confidence interval [CI]: 7.1–19.2) and 10.4% (95% CI: 5.4–15.3) of women versus 10.6% (95%CI: 1.5–19.7) and 1.7% (95%CI: 0–4.1) in subjects from the general population, respectively. Conclusion Young adults infected with HIV since childhood had a higher prevalence of dyslipidemia and metabolically detrimental fat distribution than adults of same age of the general population, supporting close monitoring for cardiometabolic diseases.