Open AccessSomatosensory and transcranial motor evoked potential monitoring in a porcine model for experimental procedures
Author(s) -
Sven Maier,
Ulrich Goebel,
Sonja Krause,
Christoph Benk,
Martin Alexander Schick,
Hartmut Buerkle,
Friedhelm Beyersdorf,
Fabian A. Kari,
Jakob Wollborn
Publication year - 2018
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0205410
Subject(s) - modalities , medicine , computer science , set (abstract data type) , animal model , neuroscience , clinical practice , physical medicine and rehabilitation , intensive care medicine , medical physics , psychology , physical therapy , social science , sociology , programming language
Evoked potential monitoring has evolved as an essential tool not only for elaborate neurological diagnostics, but also for general clinical practice. Moreover, it is increasingly used to guide surgical procedures and prognosticate neurological outcome in the critical care unit, e.g. after cardiac arrest. Experimental animal models aim to simulate a human-like scenario to deduct relevant clinical information for patient treatment and to test novel therapeutic opportunities. Porcine models are particularly ideal due to a comparable cardiovascular system and size. However, certain anatomic disparities have to be taken into consideration when evoked potential monitoring is used in animal models. We describe a non-invasive and reproducible set-up useful for different modalities in porcine models. We further illustrate hints to overcome multi-faceted problems commonly occurring while using this sophisticated technique. Our descriptions can be used to answer a plethora of experimental questions, and help to further facilitate experimental therapeutic innovation.