Open AccessA stochastic model of myeloid cell lineages in hematopoiesis and pathway mutations in acute myeloid leukemia
Author(s) -
Frank Jäkel,
Oliver Worm,
Adam Lange,
Roland Mertelsmann
Publication year - 2018
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0204393
Subject(s) - haematopoiesis , myeloid , myeloid leukemia , biology , stem cell , myeloid cells , leukemia , cancer research , microbiology and biotechnology , cellular differentiation , mutation , immunology , genetics , gene
A model for hematopoiesis is presented that explicitly includes the erythrocyte, granulocyte, and thrombocyte lineages and their common precursors. A small number of stem cells proliferate and differentiate through different compartments to produce the vast number of blood cells needed every day. Growth factors regulate the proliferation of cells dependent on the current demand. We provide a steady state analysis of the model and rough parameter estimates. Furthermore, we extend the model to include mutations that alter the replicative capacity of cells and introduce differentiation blocks. With these mutations the model develops signs of acute myeloid leukemia.