Open AccessSynthesis and characterization of salen-Ti(IV) complex and application in the controllable polymerization of D, L-lactide
Author(s) -
Xiang Li,
Bao-Jun Yang,
Huaili Zheng,
Pei Ying Wu,
Guoming Zeng
Publication year - 2018
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0201054
Subject(s) - biocompatibility , dispersity , polymerization , lactide , catalysis , ring opening polymerization , lactic acid , polymer chemistry , materials science , chemistry , polymer , organic chemistry , metallurgy , biology , bacteria , genetics
Poly(lactic acid) has been extensively investigated in the biomedical field because of its good biocompatibility and biodegradability. As an important method of poly(lactic acid) synthesis, metal complex-catalyzed ring-opening polymerization (ROP) of lactide can achieve a controllable lactide polymerization through the selection of appropriate ligands and metals. In this study, a novel metal (LTi–O) 2 complex was synthesized and structurally characterized. (LTi–O) 2 showed a relatively high catalytic activity and controllability of Poly(D, L-lactide) (PDLLA) molecular weights (polydispersity index of 1.02–1.22) in the ROP of D,L-lactide. The kinetic equation of D,L-LA ROP catalyzed by (LTi–O) 2 could be expressed as– d [M]/ dt = k [M] 2 [(LTi–O) 2 ] 1 , and the reaction activation energy was 95.67 kJ·mol −1 . Physical/chemical properties and biocompatibility evaluation results showed that PDLLA obtained through the (LTi–O) 2 -catalyzed ROP of D,L- lactide exhibited a good degradation performance and excellent biocompatibility.