Open AccessUtility of high b-value (2000 sec/mm2) DWI with RESOLVE in differentiating papillary thyroid carcinomas and papillary thyroid microcarcinomas from benign thyroid nodules
Author(s) -
Qingjun Wang,
Yumei Guo,
Jing Zhang,
LiJing Shi,
Hao-yong Ning,
Xiliang Zhang,
Yuanyuan Lu
Publication year - 2018
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0200270
Subject(s) - medicine , thyroid nodules , thyroid , receiver operating characteristic , thyroid cancer , radiology , nuclear medicine , thyroid carcinoma , papillary thyroid cancer , ultrasound
Purpose The aim of the study was to evaluate the role of high b-value (2000 sec/mm 2 ) diffusion-weighted imaging (DWI) by using Readout Segmentation of Long Variable Echo-trains (RESOLVE) in differentiating papillary thyroid carcinomas (PTCs) and papillary thyroid microcarcinomas (PTMCs) from benign thyroid nodules. Materials and methods Consecutive patients with thyroid nodules scheduled for surgery underwent high b-value DWI with 3 b-values: 0, 800 and 2000 sec/mm 2 . Signal intensity ratios (SIRs) of thyroid nodules to adjacent normal thyroid tissue on DWI were measured as: SIR b0 , SIR b800 and SIR b2000 . Apparent diffusion coefficient (ADC) values based on the 3 different b-values were acquired as: ADC b0-800 , ADC b0-2000 , and ADC b0-800-2000 . The 6 diagnostic indicators were evaluated by receiver operating characteristic (ROC) and diagnostic ability was compared between high b-value DWI and Ultrasound (US). Results A total of 52 PTCs including 33 PTMCs (38 patients, 8 men and 30 women, aged 45.68 ± 11.93 years) and 62 benign thyroid nodules (46 patients, 7 men and 39 women, aged 48.73 ± 11.98 years) were enrolled into the final statistical analysis. ADC b0-800-2000 had the highest diagnostic ability in differentiating PTCs from benign thyroid nodules with area under curve (AUC) of 0.944, sensitivity of 96.15% and specificity of 85.48%, and PTMCs from benign thyroid nodules with AUC of 0.940, sensitivity of 93.94% and specificity of 85.48%. On the strength of lower false-positive rates than US (14.52% vs. 32.26% for PTCs and 14.52% vs. 32.26% for PTMCs), ADC b0-800-2000 had significantly better diagnostic ability in PTCs ( P = 0.002) and PTMCs ( P = 0.005). Conclusion High b-value (2000 sec/mm 2 ) DWI can contribute to differentiating PTCs and PTMCs from benign thyroid nodules and can be potentially used as an active surveillance imaging method for PTMCs.