Open AccessGender difference in the relationship between the ferritin and homeostasis model assessment of insulin resistance in non-diabetic Korean adults
Author(s) -
Hyun Ju Yoon,
Yoon Sik Kim,
Jun Ho Lee,
Mi Young Gi,
Ju Ae,
Jeong-Min Seong
Publication year - 2018
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0199465
Subject(s) - insulin resistance , ferritin , medicine , national health and nutrition examination survey , confidence interval , menopause , homeostasis , endocrinology , postmenopausal women , insulin , population , environmental health
Background The present study was conducted to assess gender difference in the relationship between the ferritin and homeostasis model assessment of insulin resistance (HOMA-IR) and beta cell function (HOMA- B ) in non-diabetic Korean adults. Materials and methods A sample including 5,414 adults (2,279 men, 1,529 postmenopausal women, and 1,606 premenopausal women) aged ≥ 20 years from the fifth Korean National Health and Nutrition Examination Survey (KNHANES V-1, 2010) was analyzed. Results There were several key findings in the present study. First, in men, HOMA-IR (β = 0.119, 95% confidence interval [CI], 3.304 to 8.003) constituted the independent factor determining ferritin, but this was not the case for HOMA- B (β = -0.042, 95% CI, -0.100 to 0.011). Second, in postmenopausal women, HOMA-IR (β = 0.087, 95% CI, 0.899 to 5.238) was the independent factor determining ferritin, but this was not the case for HOMA- B (β = -0.043, 95% CI, -0.065 to 0.010). Third, in premenopausal women, neither HOMA-IR (β = -0.050, 95% CI, -3.056 to 0.364) nor HOMA- B (β = -0.009, 95% CI, -0.028 to 0.020) constituted the independent factors determining ferritin. Conclusions Ferritin was positively associated with insulin resistance in non-diabetic Korean men and postmenopausal women, but not in non-diabetic Korean premenopausal women.