Open AccessA class of hydrazones are active against non-replicating Mycobacterium tuberculosis
Author(s) -
Shilah A. Bonnett,
Devon Dennison,
Megan Files,
Anumita Bajpai,
Tanya Parish
Publication year - 2018
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0198059
Subject(s) - mycobacterium tuberculosis , tuberculosis , microbiology and biotechnology , bacteria , bacilli , mycobacterium , biology , antibiotics , chemistry , medicine , genetics , pathology
There is an urgent need for the development of shorter, simpler and more tolerable drugs to treat antibiotic tolerant populations of Mycobacterium tuberculosis . We previously identified a series of hydrazones active against M . tuberculosis . We selected five representative compounds for further analysis. All compounds were active against non-replicating M . tuberculosis , with two compounds demonstrating greater activity under hypoxic conditions than aerobic culture. Compounds had bactericidal activity with MBC/MIC of < 4 and demonstrated an inoculum-dependent effect against aerobically replicating bacteria. Bacterial kill kinetics demonstrated a faster rate of kill against non-replicating bacilli generated by nutrient starvation. Compounds had limited activity against other bacterial species. In conclusion, we have demonstrated that hydrazones have some attractive properties in terms of their anti-tubercular activity.