Lung density change after SABR: A comparative study between tri-Co-60 magnetic resonance-guided system and linear accelerator

Radiation-induced lung damage is an important treatment-related toxicity after lung stereotactic ablative radiotherapy (SABR). After implementing a tri- 60 Co magnetic-resonance image guided system, ViewRay TM , we compared the associated early radiological lung density changes to those associated with a linear accelerator (LINAC). Eight patients treated with the tri- 60 Co system were matched 1:1 with patients treated with LINAC. Prescription doses were 52 Gy or 60 Gy in four fractions, and lung dose-volumetric parameters were calculated from each planning system. The first two follow-up computed tomography (CT) were co-registered with the planning CT through deformable registration software, and lung density was measured by isodose levels. Tumor size was matched between the two groups, but the planning target volume of LINAC was larger than that of the tri- 60 Co system ( p = 0.036). With regard to clinically relevant dose-volumetric parameters in the lungs, the ipsilateral lung mean dose, V 10Gy and V 20Gy were significantly poorer in tri- 60 Co plans compared to LINAC plans ( p = 0.012, 0.036, and 0.017, respectively). Increased lung density was not observed in the first follow-up scan compared to the planning scan. A significant change of lung density was shown in the second follow-up scan and there was no meaningful difference between the tri- 60 Co system and LINAC for all dose regions. In addition, no patient developed clinical radiation pneumonitis until the second follow-up scan. Therefore, there was no significant difference in the early radiological lung damage between the tri- 60 Co system and LINAC for lung SABR despite of the inferior plan quality of the tri- 60 Co system compared to that of LINAC. Further studies with a longer follow-up period are needed to confirm our findings.