Open AccessA Boolean network of the crosstalk between IGF and Wnt signaling in aging satellite cells
Author(s) -
Lea Siegle,
Julian Schwab,
Silke D. Kühlwein,
Ludwig Lausser,
Stefan Tümpel,
Astrid S. Pfister,
Michael Kühl,
Hans A. Kestler
Publication year - 2018
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0195126
Subject(s) - wnt signaling pathway , crosstalk , biology , in silico , signal transduction , microbiology and biotechnology , computational biology , bioinformatics , genetics , gene , engineering , electronic engineering
Aging is a complex biological process, which determines the life span of an organism. Insulin-like growth factor (IGF) and Wnt signaling pathways govern the process of aging. Both pathways share common downstream targets that allow competitive crosstalk between these branches. Of note, a shift from IGF to Wnt signaling has been observed during aging of satellite cells. Biological regulatory networks necessary to recreate aging have not yet been discovered. Here, we established a mathematical in silico model that robustly recapitulates the crosstalk between IGF and Wnt signaling. Strikingly, it predicts critical nodes following a shift from IGF to Wnt signaling. These findings indicate that this shift might cause age-related diseases.