A Boolean network of the crosstalk between IGF and Wnt signaling in aging satellite cells | Zendy

Lea Siegle | Zendy; Julian Schwab | Zendy; Silke D. Kühlwein | Zendy; Ludwig Lausser | Zendy; Stefan Tümpel | Zendy; Astrid S. Pfister | Zendy; Michael Kühl | Zendy; Hans A. Kestler | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

A Boolean network of the crosstalk between IGF and Wnt signaling in aging satellite cells

Author(s) -

Lea Siegle,

Julian Schwab,

Silke D. Kühlwein,

Ludwig Lausser,

Stefan Tümpel,

Astrid S. Pfister,

Michael Kühl,

Hans A. Kestler

Publication year - 2018

Publication title -

plos one

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.99

H-Index - 332

ISSN - 1932-6203

DOI - 10.1371/journal.pone.0195126

Subject(s) - wnt signaling pathway , crosstalk , biology , in silico , signal transduction , microbiology and biotechnology , computational biology , bioinformatics , genetics , gene , engineering , electronic engineering

Aging is a complex biological process, which determines the life span of an organism. Insulin-like growth factor (IGF) and Wnt signaling pathways govern the process of aging. Both pathways share common downstream targets that allow competitive crosstalk between these branches. Of note, a shift from IGF to Wnt signaling has been observed during aging of satellite cells. Biological regulatory networks necessary to recreate aging have not yet been discovered. Here, we established a mathematical in silico model that robustly recapitulates the crosstalk between IGF and Wnt signaling. Strikingly, it predicts critical nodes following a shift from IGF to Wnt signaling. These findings indicate that this shift might cause age-related diseases.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research