Open AccessAnalysis of LCT-13910 genotypes and bone mineral density in ancient skeletal materials
Author(s) -
Barbara Mnich,
Anna Spinek,
Maciej Chyleński,
Aleksandra Sommerfeld,
Mirosława Dabert,
Anna Juras,
Krzysztof Szostek
Publication year - 2018
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0194966
Subject(s) - osteoporosis , bone mineral , osteopenia , bone density , population , medicine , genotype , endocrinology , biology , genetics , environmental health , gene
The relation of LCT-13910 genotypes and bone mineral density (BMD) has been the subject of modern-day human population studies, giving inconsistent results. In the present study we analyze for the first time a relation of LCT-13910 genotypes and BMD in historical skeletal individuals. Ancient population might be a model for testing this association due to elimination of non-natural factors affecting bone density. Among 22 medieval individuals from Sanok churchyard (South-Eastern Poland; dated from XIV to XVII c. AD) we identified 4 individuals with osteoporosis (mean BMD = 0.468 g/cm 2 , SD = 0.090), 10 individuals with osteopenia (mean BMD = 0.531 g/cm 2 , SD = 0.066) and 8 individuals with normal BMD values (mean BMD = 0,642 g/cm 2 , SD = 0.060). Analyses of BMD and LCT-13910 genotypes revealed that mean BMD was the highest (0.583 g/cm 2 , SD = 0.065) in the individuals with lactose tolerance genotypes (TT and CT). We also found possible association of lower BMD at the radius and CC genotypes due to higher but not statistically significant frequency of osteoporosis in the lactose intolerant group ( p = 0.60). Statistically significant correlation was found between BMD and females aged 20–35 years, with tendency to reduce BMD with age ( p = 0.02).