Open AccessNoninvasive measurement of dynamic brain signals using light penetrating the brain
Author(s) -
Osamu Hiwaki,
Hajime Miyaguchi
Publication year - 2018
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0192095
Subject(s) - electrophysiology , somatosensory system , somatosensory evoked potential , neuroscience , brain function , skull , brain activity and meditation , signal (programming language) , neurophysiology , signal averaging , electroencephalography , biology , computer science , anatomy , programming language , signal transfer function , digital signal processing , analog signal , computer hardware
Conventional techniques for the noninvasive measurement of brain activity involve critical limitations in spatial or temporal resolution. Here, we propose the method for noninvasive brain function measurement with high spatiotemporal resolution using optical signals. We verified that diffused near-infrared light penetrating through the upper jaw and into the skull, which we term as optoencephalography (OEG), leads to the detection of dynamic brain signals that vary concurrently with the electrophysiological neural activity. We measured the OEG signals following the stimulation of the median nerve in common marmosets. The OEG signal response was tightly coupled with the electrophysiological response represented by the somatosensory evoked potential (SSEP). The OEG measurement is also shown to offer rather clear discrimination of brain signals.