Open Access+mRNA expression of LRRC55 protein (leucine-rich repeat-containing protein 55) in the adult mouse brain
Author(s) -
Yingying Zhang,
Xue Han,
Ye Liu,
Jian Chen,
Hua Lu,
Qian Ma,
Yangyuxin Huang,
Qiong-Yao Tang,
Zhe Zhang
Publication year - 2018
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0191749
Subject(s) - cerebellum , bk channel , messenger rna , in situ hybridization , biology , protein subunit , potassium channel , pons , microbiology and biotechnology , central nervous system , neuroscience , gene , endocrinology , genetics
LRRC55 (leucine-rich repeat-containing protein 55) protein is an auxiliary γ subunit of BK (Big conductance potassium channel) channels, which leftward shifts GVs of BK channels around 50 mV in the absence of cytosolic Ca 2+ . LRRC55 protein is also the only γ subunit of BK channels that is expressed in mammalian nervous system. However, the expression pattern of LRRC55 gene in adult mammalian brain remains elusive. In this study, we investigated the distribution of LRRC55 mRNA in the adult mouse brain by using in situ hybridization. We found that LRRC55 mRNA is richly expressed in the adult mouse medial habenula nucleus (MHb), cerebellum and pons. However, the potential role of LRRC55 in MHb and cerebellum could be different based on the function of BK channels in these brain regions.