Detection of trace concentrations of S-nitrosothiols by means of a capacitive sensor | Zendy

James M. Seckler | Zendy; Nikki M. Meyer | Zendy; Spencer T. Burton | Zendy; James N. Bates | Zendy; Benjamin Gaston | Zendy; Stephen J. Lewis | Zendy

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Detection of trace concentrations of S-nitrosothiols by means of a capacitive sensor

Author(s) -

James M. Seckler,

Nikki M. Meyer,

Spencer T. Burton,

James N. Bates,

Benjamin Gaston,

Stephen J. Lewis

Publication year - 2017

Publication title -

plos one

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.99

H-Index - 332

ISSN - 1932-6203

DOI - 10.1371/journal.pone.0187149

Subject(s) - capacitive sensing , trace (psycholinguistics) , chemistry , molecule , nanotechnology , biological system , biophysics , materials science , computer science , biology , organic chemistry , philosophy , linguistics , operating system

Small molecule S-nitrosothiols are a class of endogenous chemicals in the body, which have been implicated in a variety of biological functions. However, the labile nature of NO and the limits of current detection assays have made studying these molecules difficult. Here we present a method for detecting trace concentrations of S-nitrosothiols in biological fluids. Capacitive sensors when coupled to a semiconducting material represent a method for detecting trace quantities of a chemical in complex solutions. We have taken advantage of the semiconducting and chemical properties of polydopamine to construct a capacitive sensor and associated method of use, which specifically senses S-nitrosothiols in complex biological solutions.

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