Open AccessAssociation of birth weight with corneal power in early adolescence: Results from the National Health and Nutrition Examination Survey (NHANES) 1999–2008
Author(s) -
Achim Fieß,
Alexander K. Schuster,
Norbert Pfeiffer,
Stefan Nickels
Publication year - 2017
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0186723
Subject(s) - national health and nutrition examination survey , astigmatism , birth weight , keratometer , visual acuity , medicine , logistic regression , refractive error , low birth weight , demography , ophthalmology , biology , pregnancy , physics , environmental health , population , sociology , optics , genetics
Purpose To analyze the effect of birth weight on ocular morphology, refraction and visual function in early adolescents aged 12–15 years. Material and methods We conducted a secondary data analysis using the public use files from the National Health and Nutrition Examination Survey of the period from 1999 to 2008. Study participants aged 12 to 15 years were included with data on birth weight and ophthalmic parameters including presenting distance visual acuity, objective refraction and keratometry. Visual acuity, sphere, astigmatism in power vectors J 0 and J 45 , corneal power and corneal astigmatism were evaluated for an association with birth weight. Linear and logistic regression with adjustment for age, sex, ethnicity, survey cycle and birth weight as independent variable were calculated. Results Linear regression analysis revealed an association between corneal power and birth weight (per 100g: beta = -0.04, p<0.001) in the univariate analysis, and in the model adjusted for age, sex, ethnicity and NHANES survey cycle (per 100g: beta = -0.04, p<0.001). A lower birth weight was associated with higher corneal power. We found no evidence for an association of visual acuity, sphere, spherical equivalent, J 0 -vector and J 45 -vector of astigmatism, corneal J 0 - or corneal J 45 -vector with birth weight. Conclusion Our data demonstrate that low BW is linked to alterations in keratometric power even in early adolescents aged 12–15 years whereas visual acuity and refractive error showed no association.