Open AccessCorrelation of serum cartilage oligometric matrix protein (COMP) and interleukin-16 (IL-16) levels with disease severity in primary knee osteoarthritis: A pilot study in a Malaysian population
Author(s) -
Ekta Gupta,
Wei Ren Ng,
Shew Fung Wong,
Abdul Kareem Bhurhanudeen,
Swan Sim Yeap
Publication year - 2017
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0184802
Subject(s) - osteoarthritis , cartilage oligomeric matrix protein , medicine , correlation , interleukin , interleukin 17 , knee cartilage , population , cartilage , immunology , physical therapy , pathology , inflammation , articular cartilage , cytokine , mathematics , anatomy , alternative medicine , environmental health , geometry
Objective The aim of this study was to investigate the correlations between serum cartilage oligomeric matrix protein (COMP), interleukin-16 (IL-16) and different grades of knee osteoarthritis (KOA) in Malaysian subjects. Methods Ninety subjects were recruited comprising 30 with Kellgren-Lawrence (K-L) grade 2 KOA, 27 with K-L grade 3 KOA, 7 with grade 4 KOA, and 30 healthy controls. All subjects completed the Western Ontario and McMaster Universities Arthritis Index (WOMAC) questionnaire. Serum COMP and IL-16 levels were measured using ELISA and their values log transformed to ensure a normal distribution. Results There was no significant differences in levels of log serum COMP and IL-16 between healthy controls and KOA patients. There were no significant differences in the log serum COMP and IL-16 levels within the different K-L grades in the KOA patients. In KOA patients, log serum IL-16 levels significantly correlated with the WOMAC score ( p = 0.001) and its subscales, pain ( p = 0.005), stiffness ( p = 0.019) and physical function ( p <0.0001). Serum IL-16 levels were significantly higher in Malaysian Indians compared to Malays and Chinese ( p = 0.024). Conclusions In this multi-ethnic Malaysian population, there was no difference in serum COMP and IL-16 levels between healthy controls and patients with KOA, nor was there any difference in serum COMP or IL-16 levels across the various K-L grades of KOA. However, there were significant inter-racial differences in serum IL-16 levels.