Open AccessComprehensive metabolic characterization of serum osteocalcin action in a large non-diabetic sample
Author(s) -
Lukas Entenmann,
Maik Pietzner,
Anna Artati,
Anke Hannemann,
Ann-Kristin Henning,
Gabi Kastenmüller,
Henry Völzke,
Matthias Nauck,
Jerzy Adamski,
Henri Wallaschofski,
Nele Friedrich
Publication year - 2017
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0184721
Subject(s) - osteocalcin , catabolism , metabolism , endocrinology , medicine , metabolic pathway , chemistry , biology , biochemistry , enzyme , alkaline phosphatase
Recent research suggested a metabolic implication of osteocalcin (OCN) in e.g. insulin sensitivity or steroid production. We used an untargeted metabolomics approach by analyzing plasma and urine samples of 931 participants using mass spectrometry to reveal further metabolic actions of OCN. Several detected relations between OCN and metabolites were strongly linked to renal function, however, a number of associations remained significant after adjustment for renal function. Intermediates of proline catabolism were associated with OCN reflecting the implication in bone metabolism. The association to kynurenine points towards a pro-inflammatory state with increasing OCN. Inverse relations with intermediates of branch-chained amino acid metabolism suggest a link to energy metabolism. Finally, urinary surrogate markers of smoking highlight its adverse effect on OCN metabolism. In conclusion, the present study provides a read-out of metabolic actions of OCN. However, most of the associations were weak arguing for a limited role of OCN in whole-body metabolism.