Open AccessNuclear envelope-distributed CD147 interacts with and inhibits the transcriptional function of RING1 and promotes melanoma cell motility
Author(s) -
Junchen Chen,
Cong Peng,
Lei Li,
Jianglin Zhang,
Weiqi Zeng,
Xiang Chen
Publication year - 2017
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0183689
Subject(s) - melanoma , motility , biology , transmembrane protein , phenotype , microbiology and biotechnology , cancer research , cell , genetics , gene , receptor
Melanoma accounts for nearly 80% of all deaths associated with skin cancer. CD147 plays a very important role in melanoma progression and the expression level may correlate with tumor malignancy. RING1 can bind DNA and act as a transcriptional repressor, play an important role in the aggressive phenotype in melanoma. The interactions between CD147 and RING1 were identified with a yeast two-hybrid and RING1 interacted with CD147 through the transmembrane domain. RING1 inhibits CD147 ’s capability promoting melanoma cell migration. In conclusion, the study identified novel interactions between CD147 and RING1 , recovered CD147 nuclear envelope distribution in melanoma cells, and suggested a new mechanism underlying how cytoplasmic CD147 promotes melanoma development.