Open AccessModulation of platelet-derived microparticles to adhesion and motility of human rheumatoid arthritis fibroblast-like synoviocytes
Author(s) -
Lei Wang,
Jiahuan Liu,
Bing Yang,
Zhongshuang Ma,
Guiping Liu,
Weishou Shen,
Yu Zhang
Publication year - 2017
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0181003
Subject(s) - motility , extracellular matrix , fibroblast , mapk/erk pathway , rheumatoid arthritis , chemistry , matrix metalloproteinase , mmp1 , adhesion , microbiology and biotechnology , cancer research , immunology , signal transduction , medicine , biology , biochemistry , in vitro , gene expression , organic chemistry , gene
Platelet-derived microparticles (PMPs) are closely associated with disease activity in rheumatoid arthritis (RA) and contribute to the inflammatory process. Rheumatoid arthritis fibroblast-like synoviocytes (RA-FLSs) play important roles in the progression of joint destruction. The aim of this study is to demonstrate whether PMPs affect the adhesion and motility of RA-FLSs. Our data indicated that PMPs promoted migration, invasion and adhesion to extracellular matrix (ECM) of RA-FLSs. Further study showed that PMPs up-regulated the expression of matrix metalloproteinase-1 (MMP1) and increased the level of phosphorylation of NF-κB (p-NF-κB) and Erk (p-Erk) in RA-FLSs. These results suggest that PMPs promote RA-FLSs adhesion and motility presumably by increasing MMP1 via activating Erk-mediated NF-κB pathway.