Open AccessFasting plasma glucose and serum uric acid levels in a general Chinese population with normal glucose tolerance: A U-shaped curve
Author(s) -
Yunyang Wang,
Jen-Tsan Chi,
Kui Che,
Ying Chen,
Xiaolin Sun,
Yangang Wang,
Zhongchao Wang
Publication year - 2017
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0180111
Subject(s) - uric acid , medicine , plasma glucose , endocrinology , glucose tolerance test , chinese population , population , diabetes mellitus , chemistry , biochemistry , insulin resistance , environmental health , genotype , gene
Objective Although several epidemiological studies assessed the relationship between fasting plasma glucose (FPG) and serum uric acid (SUA) levels, the results were inconsistent. A cross-sectional study was conducted to investigate this relationship in Chinese individuals with normal glucose tolerance. Research design and methods A total of 5,726 women and 5,457 men with normal glucose tolerance were enrolled in the study. All subjects underwent a 75-g oral glucose tolerance test. Generalized additive models and two-piecewise linear regression models were applied to assess the relationship. Results A U-shaped relationship between FPG and SUA was observed. After adjusting for potential confounders, the inflection points of FPG levels in the curves were 4.6 mmol/L in women and 4.7 mmol/L in men respectively. SUA levels decreased with increasing fasting plasma glucose concentrations before the inflection points (regression coefficient [ β ] = -36.4, P < 0.001 for women; β = -33.5, P < 0.001 for men), then SUA levels increased ( β = 17.8, P < 0.001 for women; β = 13.9, P < 0.001 for men). Additionally, serum insulin levels were positively associated with FPG and SUA ( P < 0.05). Conclusions A U-shaped relationship between FPG and SUA levels existed in Chinese individuals with normal glucose tolerance. The association is partly mediated through serum insulin levels.