Open Access18F-FDG silicon photomultiplier PET/CT: A pilot study comparing semi-quantitative measurements with standard PET/CT
Author(s) -
Lucia Baratto,
Sonya Young Park,
Negin Hatami,
Guido Davidzon,
Shyam Srinivas,
Sanjiv S. Gambhir,
Andrei Iagaru
Publication year - 2017
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0178936
Subject(s) - silicon photomultiplier , positron emission tomography , nuclear medicine , photomultiplier , pet ct , materials science , medicine , biomedical engineering , physics , optics , scintillator , detector
Purpose To evaluate if the new Discovery Molecular Insights (DMI) PET/CT scanner provides equivalent results compared to the standard of care PET/CT scanners (GE Discovery 600 or GE Discovery 690) used in our clinic and to explore any possible differences in semi-quantitative measurements. Methods The local Institutional Review Board approved the protocol and written informed consent was obtained from each patient. Between September and November 2016, 50 patients underwent a single 18 F-FDG injection and two scans: the clinical standard PET/CT followed immediately by the DMI PET/CT scan. We measured SUV max and SUV mean of different background organs and up to four lesions per patient from data acquired using both scanners. Results DMI PET/CT identified all the 107 lesions detected by standard PET/CT scanners, as well as additional 37 areas of focal increased 18 F-FDG uptake. The SUV max values for all 107 lesions ranged 1.2 to 14.6 (mean ± SD: 2.8 ± 2.8), higher on DMI PET/CT compared with standard of care PET/CT. The mean lesion:aortic arch SUV max ratio and mean lesion:liver SUV max ratio were 0.2–15.2 (mean ± SD: 3.2 ± 2.6) and 0.2–8.5 (mean ± SD: 1.9 ± 1.4) respectively, higher on DMI PET/CT than standard PET/CT. These differences were statistically significant ( P value < 0.0001) and not correlated to the delay in acquisition of DMI PET data ( P < 0.0001). Conclusions Our study shows high performance of the new DMI PET/CT scanner. This may have a significant role in diagnosing and staging disease, as well as for assessing and monitoring responses to therapies.