Open AccessLung function decline in subjects with and without COPD in a population-based cohort in Latin-America
Author(s) -
Rogelio Pérez Padilla,
Rosario Fernández-Plata,
María Montes de,
María Victorina López-Varela,
José Roberto Jardim,
Adriana Muiño,
Gonzalo Valdívia,
Ana Maria Baptista Menezes
Publication year - 2017
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0177032
Subject(s) - copd , medicine , cohort , asthma , population , wheeze , lung function , cohort study , obstructive lung disease , pulmonary function testing , demography , lung , environmental health , sociology
Background Lung-function decline is one of the possible mechanisms leading to Chronic Obstructive Pulmonary Disease (COPD). Methods We analyzed data obtained from two population-based surveys of adults (n = 2026) conducted in the same individuals 5–9 years (y) after their baseline examination in three Latin-American cities. Post BronchoDilator (postBD) FEV 1 decline in mL/y, as %predicted/y (%P/y) and % of baseline/y (%B/y) was calculated and the influence of age, gender, BMI, baseline lung function, BD response, exacerbations rate evaluated using multivariate models. Results Expressed in ml/y, the mean annual postBD FEV 1 decline was 27 mL (0.22%P, 1.32%B) in patients with baseline COPD and 36 (0.14%P, 1.36%B) in those without. Faster decline (in mL/y) was associated with higher baseline lung function, with significant response to bronchodilators, older age and smoking at baseline, also in women with chronic cough and phlegm, or ≥2 respiratory exacerbations in the previous year, and in men with asthma. Conclusions Lung function decline in a population-based cohort did not differ in obstructed and non-obstructed individuals, it was proportional to baseline FEV 1 , and was higher in smokers, elderly, and women with respiratory symptoms.