Open AccessPositive association between ALDH2 rs671 polymorphism and essential hypertension: A case-control study and meta-analysis
Author(s) -
Yinyin Wu,
Juntao Ni,
Xiuyu Cai,
Fuzhi Lian,
Haiyan Ma,
Liangwen Xu,
Lei Yang
Publication year - 2017
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0177023
Subject(s) - aldh2 , odds ratio , meta analysis , confidence interval , allele , genetics , genotype , polymorphism (computer science) , case control study , biology , genetic model , medicine , gene
Background and objective Several studies have been conducted to examine the association between aldehyde dehydrogenase 2 family ( ALDH2 ) rs671 polymorphism and essential hypertension (EH). However, the results remain inconsistent. This study aimed to clarify the association between ALDH2 rs671 polymorphism and EH susceptibility. Methods One thousand and ninety-four cases and 1236 controls who were ethnic Han Chinese were collected for this population-based case-control study. A meta-analysis was performed to calculate the pooled odds ratio and 95% confidence interval, using allele contrast, dominant, recessive, and co-dominant models using fixed or random-effect models. Results Significant differences were observed between EH cases and controls at the level of both genotype (χ 2 = 6.656, P<0.05) and alleles (χ 2 = 6.314, P<0.05). An additional meta-analysis using 4204 cases and 5435 controls established that rs671 was significantly associated with EH (P<0.00001). Conclusion The results of our case-control study and meta-analysis showed that there is a significant association between ALDH2 rs671 polymorphism and EH susceptibility. In addition, the results of the breakdown analysis by gender suggest a male-specific association between the ALDH2 rs671 polymorphism and EH.