Open AccessSerum irisin levels correlated to peritoneal dialysis adequacy in nondiabetic peritoneal dialysis patients
Author(s) -
Yuhai Zhang,
Zengchun Ye,
Jun Zhang,
Yanru Chen,
Cailian Cheng,
Cheng Wang,
Xun Liu,
Tanqi Lou,
Hui Peng
Publication year - 2017
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0176137
Subject(s) - peritoneal dialysis , medicine , dialysis , gastroenterology , intensive care medicine , urology
Background Irisin is a recently discovered myokine thought to be involved in multiple metabolism abnormalities in most dialysis patients. However, the myokine has not been thoroughly studied in peritoneal dialysis. This study aimed to evaluate serum irisin levels and establish their relation to dialysis adequacy, insulin resistance, and bone metabolism status in patients on peritoneal dialysis. Methods A total of 59 nondiabetic prevalent peritoneal dialysis patients and 52 age- and sex-matched healthy controls were enrolled in this cross-sectional study. Serum irisin concentration was assessed by enzyme-linked immunosorbent assay. The correlations between serum irisin and dialysis adequacy, clinical, and metabolic variables were investigated. Results Serum irisin levels were lower in nondiabetic peritoneal dialysis patients (17.02ng/ml) compared with healthy controls (22.17ng/ml, P<0.001). Multivariate regression analysis revealed that fasting glucose levels were correlated inversely with serum irisin levels in peritoneal dialysis patients. Serum irisin levels were associated with neither insulin resistance nor bone metabolism in our patients. Serum irisin levels were positively associated with peritoneal Kt/V urea (β = 4.933, 95% confidence interval [CI] = 0.536–9.331, P = 0.029) and peritoneal C Cr (β = 0.259, 95% CI = 0.053–0.465, P = 0.015) among peritoneal dialysis patients. Conclusions The study demonstrated that non-diabetic peritoneal dialysis patients have lower serum irisin levels, and the levels were correlated with peritoneal dialysis adequacy, indicating adequate dialysis may improve irisin secretion. Additional studies are needed to provide a confirmation.