Open AccessGenetic variant of miR-4293 rs12220909 is associated with susceptibility to non-small cell lung cancer in a Chinese Han population
Author(s) -
Lixia Fan,
Linqi Chen,
Xiaoling Ni,
Shicheng Guo,
Yinghui Zhou,
Chenji Wang,
Yabiao Zheng,
Fangyuan Shen,
Vijay Kumar Kolluri,
Merlin Muktiali,
Zhenhong Zhao,
Junjie Wu,
Dongdong Zhao,
Zhenglei He,
Xulong Feng,
Ziyu Yuan,
Juan Zhang,
Jin Li,
Jiucun Wang,
Minghua Wang
Publication year - 2017
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0175666
Subject(s) - lung cancer , medicine , genetic predisposition , oncology , lung cancer susceptibility , population , cancer , biology , genotype , genetics , single nucleotide polymorphism , gene , disease , environmental health
Non-small cell lung cancer is one of the most common cancers and the leading cause of cancer death worldwide. Genetic variants in regulatory regions of some miRNAs might be involved in non-small cell lung cancer susceptibility and survival. rs12220909 (G/C) genetic polymorphism in miR-4293 has been shown to be associated with decreased risk of esophageal squamous cell carcinoma. However, the influence of rs12220909 genetic variation on non-small cell lung cancer susceptibility has not been reported. In order to evaluate the potential association between miR-4293 rs12220909 and non-small cell lung cancer risk in a Chinese population, we performed a case-control study among 998 non-small cell lung cancer cases and 1471 controls. The data shows that miR-4293 rs12220909 was significantly associated with decreased susceptibility to non-small cell lung cancer (GC vs.GG: OR = 0.681, 95%CI = 0.555–0.835, P = 2.19E-4; GG vs. GC+CC: OR = 0.687, 95%CI = 0.564–0.837, P = 1.95E-4), which indicates that rs12220909 in miR-4293 may play a significant role in the development of non-small cell lung cancer.