Open AccessComparison of standardized uptake value of 18F-FDG-PET-CT with 21-gene recurrence score in estrogen receptor-positive, HER2-negative breast cancer
Author(s) -
Sung Gwe Ahn,
Jae Hoon Lee,
Hak Woo Lee,
Tae Joo Jeon,
Young Hoon Ryu,
Gun Min Kim,
Joohyuk Sohn,
Mijin Yun,
Seung Ah Lee,
Jeong Eon Lee,
Seung Il Kim
Publication year - 2017
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0175048
Subject(s) - medicine , standardized uptake value , confidence interval , estrogen receptor , nuclear medicine , breast cancer , positron emission tomography , progesterone receptor , cancer
Background We investigated the relationship between 18F-fluorodeoxyglucose positron emission tomography-computed tomography (18F-FDG-PET-CT) standardized uptake value (SUV) and 21-gene recurrence score (RS) in estrogen receptor (ER)-positive/HER2-negative breast cancer. Materials and methods One hundred sixty-seven patients were identified among those who underwent preoperative 18F-FDG-PET-CT and had RS. Maximum SUV was obtained from 18F-FDG-PET-CT; the cut-off point was 4. Results The continuous RS and SUV correlated positively (Pearson’s R = 0.555; P < 0.001). An inverse correlation was found between progesterone receptor (PR) expression by reverse transcriptase-polymerase chain reaction, and SUV (Pearson’s R = -0.408; P < 0.001). Good agreement between dichotomized RS (<26 vs. ≥26) and SUV (<4 vs. ≥4) was observed in 137 of 167 patients (82.0%; 95% confidence interval [CI], 76.2–87.9). Among patients with low SUV, 114 of 115 (99.1% [95% CI, 97.4–100.0]) had tumors with lower RS (<26). Although 23 of 52 women (44.2% [95% CI, 30.7–57.7]) with high SUV had higher RS (≥26), all 13 women with high RS (≥31) had high-SUV tumors. Most cases with disagreements between SUV and RS (n = 30) were classified as high SUV/lower RS (n = 29). The discordant group had higher grade or elevated Ki67 expression (≥20%) compared with the low SUV/lower RS group (n = 109), but higher PR expression compared with the high SUV/higher RS group (n = 23). Multiple logistic regression analysis showed that high SUV were associated with higher RS (≥26). Conclusions SUV, as a biologic parameter represented using a continuous variable, was found to associate with RS in ER-positive, HER2-negative breast cancer. Further studies may reveal the biology underlying the discordance between the markers.