Open AccessMultiple functional therapeutic effects of TnP: A small stable synthetic peptide derived from fish venom in a mouse model of multiple sclerosis
Author(s) -
Evilin Naname Komegae,
Tais Matozo,
Lidiane Zito Grund,
Carla Lima,
Mônica Lopes-Ferreira
Publication year - 2017
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0171796
Subject(s) - remyelination , multiple sclerosis , experimental autoimmune encephalomyelitis , central nervous system , immunology , encephalomyelitis , inflammation , neuroprotection , medicine , biology , neuroscience , myelin
The pathological condition of multiple sclerosis (MS) relies on innate and adaptive immunity. New types of agents that beneficially modify the course of MS, stopping the progression and repairing the damage appear promising. Here, we studied Tn P, a small stable synthetic peptide derived from fish venom in the control of inflammation and demyelination in experimental autoimmune encephalomyelitis as prophylactic treatment. Tn P decreased the number of the perivascular infiltrates in spinal cord, and the activity of MMP-9 by F4/80+ macrophages were decreased after different regimen treatments. Tn P reduces in the central nervous system the infiltration of IFN-γ-producing Th1 and IL-17A-producing Th17 cells. Also, treatment with therapeutic Tn P promotes the emergence of functional Treg in the central nervous system entirely dependent on IL-10. Therapeutic Tn P treatment accelerates the remyelination process in a cuprizone model of demyelination. These findings support the beneficial effects of Tn P and provides a new therapeutic opportunity for the treatment of MS.