Open AccessRelationship of Serum Betatrophin with Nonalcoholic Fatty Liver in a Chinese Population
Author(s) -
Wen Hu,
Xiaojuan Shao,
DeAn Guo,
Huifeng Hao,
Yong Zhang,
Mingfeng Xia,
Yingyun Gong,
Hongwen Zhou,
Yun-qing Fan,
Yu Wang
Publication year - 2017
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0170758
Subject(s) - nonalcoholic fatty liver disease , medicine , fatty liver , odds ratio , gastroenterology , anthropometry , stepwise regression , endocrinology , population , logistic regression , case control study , disease , environmental health
Objective This study aimed to investigate the association of serum betatrophin with the status and progression of nonalcoholic fatty liver disease (NAFLD). Methods A total of 249 subjects who received ultrasonic examination of liver fat content (LFC) were recruited. Anthropometric and biochemical examinations were performed. Serum betatrophin was measured by ELISA. Results Compared with control group, serum betatrophin significantly increased in NAFLD group ( P < 0.05). There was significant difference in serum betatrophin among control, low liver fat content (LLFC), and high liver fat content (HLFC) groups ( P < 0.01). After adjustment for gender, age, BMI, FPG and HbA1c, the betatrophin positively correlated with LFC (r = 0.185, P < 0.01) and TG (r = 0.195, P < 0.01). Stepwise multiple regression analysis indicated serum betatrophin was independently related to LFC ( P < 0.05). Multivariate logistic regression analysis revealed subjects in the highest tertile of serum betatrophin had higher odds of having NAFLD after adjustment for traditional NAFLD risk factors (OR = 2.88, 95%CI: 1.15–7.19) (P<0.05). Conclusion Serum betatrophin is an independent risk factor for NAFLD and potential non-invasive marker for its progression. Serum betatrophin may be helpful for the early diagnosis of NAFLD and improvement of its prognosis.