Open AccessChanges in Molecular Characteristics of Mycoplasma pneumoniae in Clinical Specimens from Children in Beijing between 2003 and 2015
Author(s) -
Hongmei Sun,
Guanhua Xue,
Yan Chen,
Shaoli Li,
Huiru Zhao,
Yinchang Feng,
Liqiong Wang
Publication year - 2017
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0170253
Subject(s) - genotype , mycoplasma pneumoniae , beijing , polymerase chain reaction , biology , microbiology and biotechnology , molecular epidemiology , virology , veterinary medicine , medicine , genetics , china , gene , pneumonia , geography , archaeology
The molecular characteristics of 480 Mycoplasma pneumoniae polymerase chain reaction-positive specimens (331 were previously reported and 149 were newly reported) collected from pediatric patients in Beijing, China, between 2003 and 2015 were analyzed. Genotype M4-5-7-2/P1 were the most prevalent across the 13-year study period, although the isolation and mutation rates for this genotype varied between the periods 2003–2007, 2008–2013, and 2014–2015. In addition, there was a close association between the M4-5-7-2 genotype and macrolide resistance.