Cytosolic RNA:DNA Duplexes Generated by Endogenous Reverse Transcriptase Activity as Autonomous Inducers of Skin Inflammation in Psoriasis | Zendy

JeanPierre Molès | Zendy; Anthony Griez | Zendy; JeanJacques Guilhou | Zendy; C. Girard | Zendy; Nicolas Nagot | Zendy; Philippe Van de Perre | Zendy; Pierre Dujols | Zendy

Open Access

Cytosolic RNA:DNA Duplexes Generated by Endogenous Reverse Transcriptase Activity as Autonomous Inducers of Skin Inflammation in Psoriasis

Author(s) -

JeanPierre Molès,

Anthony Griez,

JeanJacques Guilhou,

C. Girard,

Nicolas Nagot,

Philippe Van de Perre,

Pierre Dujols

Publication year - 2017

Publication title -

plos one

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.99

H-Index - 332

ISSN - 1932-6203

DOI - 10.1371/journal.pone.0169879

Subject(s) - psoriasis , endogeny , reverse transcriptase , rna , dna , inducer , inflammation , dna damage , cytosol , proinflammatory cytokine , chemistry , biology , immunology , enzyme , biochemistry , gene

Psoriasis is a chronic skin disease of unknown ætiology. Recent studies suggested that a large amount of cytosolic DNA (cyDNA) in keratinocytes is breaking keratinocytes DNA tolerance and promotes self-sustained inflammation in the psoriatic lesion. We investigated the origin of this cyDNA. We show that, amongst all the possible DNA structures, the cyDNA could be present as RNA:DNA duplexes in keratinocytes. We further show that endogenous reverse transcriptase activities generate such duplexes and consequently activate the production of Th1-inflammatory cytokines. These observations open a new research avenue related to endogenous retroelements for the aetiology of psoriasis and probably of other human chronic inflammatory diseases.

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