Open AccessComparison of Various Indices of Energy Metabolism in Recumbent and Healthy Dairy Cows
Author(s) -
Hugues Guyot,
Johann Detilleux,
Pascal Lebreton,
Catherine Garnier,
Marie Bonvoisin,
Frédéric Rollin,
Charlotte Sandersen
Publication year - 2017
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0169716
Subject(s) - nefa , quantitative insulin sensitivity check index , insulin , medicine , homeostasis , endocrinology , insulin resistance , dairy cattle , glucose homeostasis , carbohydrate metabolism , insulin sensitivity , zoology , biology
Background Downer cow syndrome (DCS) is often diagnosed in dairy cattle during the early post-partum period. The etiology of this condition is not completely understood, as it can be related to the energetic or electrolyte metabolism, as well as to infectious diseases or to trauma. Hypothesis/Objectives The aim of this study is to compare energy metabolism and insulin sensitivity indices and various biochemical parameters between recumbent and healthy dairy cows. Animals A prospective study has been undertaken on 361 recumbent and 80 healthy Holstein cows. Methods Plasmatic glucose, insulin, non-esterified fatty acid (NEFA) and β-hydroxybutyrate (BHB) were assayed in all cows in order to calculate the insulin sensitivity indices but also minerals (Calcium, Phosphorous and Magnesium), thyroxin and creatine kinase. Body Condition Scores (BCS) was assessed. Results Significant differences in NEFA, and the glucose and insulin sensitivity indices (“Homeostasis Model Assessment” HOMA, “Revised Quantitative Insulin Sensitivity Check Index” RQUICKI, RQUICKI-BHB) were observed between healthy and recumbent cows in the early post-parturient period indicating disturbances of glucose and insulin homeostasis in the recumbent cows. In the same manner, mineral concentrations were significantly different between healthy and recumbent cows. Glucose, insulin NEFA, and HOMA, were different between early post-partum downer cows and the DCS-affected cows later in lactation. Conclusion and clinical importance Results indicate disturbances in energy homeostasis in DCS-affected dairy cows. Further research should determine a prognostic value of the indices in cows suffering from recumbency of metabolic origin.