Open AccessReproducibility for Heart Rate Variability Analysis during 6-Min Walk Test in Patients with Heart Failure and Agreement between Devices
Author(s) -
Lays Magalhães Braga,
Gustavo Faibischew Prado,
Iracema Ioco Kikuchi Umeda,
Tatiana Satie Kawauchi,
Adriana Marques Fróes Taboada,
Raymundo Soares Azevedo,
Horácio Gomes Pereira Filho,
César Grupi,
Hayala Cristina Cavenague Souza,
Dalmo Antônio Ribeiro Moreira,
Naomi Kondo Nakagawa
Publication year - 2016
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0167407
Subject(s) - heart rate variability , reproducibility , holter monitor , medicine , cardiology , concordance , heart failure , heart rate , wilcoxon signed rank test , ejection fraction , concordance correlation coefficient , ambulatory , electrocardiography , autonomic nervous system , ambulatory ecg , mann–whitney u test , statistics , mathematics , blood pressure
Heart rate variability (HRV) analysis is a useful method to assess abnormal functioning in the autonomic nervous system and to predict cardiac events in patients with heart failure (HF). HRV measurements with heart rate monitors have been validated with an electrocardiograph in healthy subjects but not in patients with HF. We explored the reproducibility of HRV in two consecutive six-minute walk tests (6MW), 60-minute apart, using a heart rate monitor (PolarS810i) and a portable electrocardiograph (called Holter) in 50 HF patients (mean age 59 years, NYHA II, left ventricular ejection fraction ~35%). The reproducibility for each device was analysed using a paired t-test or the Wilcoxon signed-rank test. Additionally, we assessed the agreement between the two devices based on the HRV indices at rest, during the 6MW and during recovery using concordance correlation coefficients (CCC), 95% confidence intervals and Bland-Altman plots. The test-retest for the HRV analyses was reproducible using Holter and PolarS810i at rest but not during recovery. In the second 6MW, patients showed significant increases in rMSSD and walking distance. The PolarS810i measurements had remarkably high concordance correlation [0.86