Open AccessOccurrence of Diverse Antimicrobial Resistance Determinants in Genetically Unrelated Biocide Tolerant Klebsiella pneumoniae
Author(s) -
Amitabha Mondal,
Manjunath Venkataramaiah,
Govindan Rajamohan,
Vijaya Bharathi Srinivasan
Publication year - 2016
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0166730
Subject(s) - klebsiella pneumoniae , microbiology and biotechnology , biology , antibiotic resistance , antimicrobial , genotype , efflux , antibiotics , pathogen , drug resistance , gene , genetics , escherichia coli
Nosocomial infections due to Klebsiella pneumoniae is a significant problem in health care settings worldwide. In this study, we examined the antimicrobial susceptibility, genetic profiles and mechanisms of antibiotic resistance in K . pneumoniae isolates of Indian origin. To our knowledge this is the first report demonstrating the high prevalence of β-lactamases, aminoglycoside modifying enzymes, quinolone resistance genes besides demonstrating the involvement of active efflux in K . pneumoniae Indian isolates. This study has enabled us to correlate the phenotypic and genotypic characteristics in K . pneumoniae , providing an important base for continued monitoring and epidemiological studies of this emerging nosocomial pathogen in Indian hospitals.