Open AccessBundled-Optode Method in Functional Near-Infrared Spectroscopy
Author(s) -
Hoang-Dung Nguyen,
Keum–Shik Hong,
YongIl Shin
Publication year - 2016
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0165146
Subject(s) - functional near infrared spectroscopy , thumb , optode , hemodynamics , haemodynamic response , nuclear magnetic resonance , spectroscopy , deoxygenated hemoglobin , biomedical engineering , hemoglobin , physics , optics , neuroscience , medicine , cardiology , anatomy , biology , blood pressure , heart rate , cognition , quantum mechanics , fluorescence , prefrontal cortex
In this paper, a theory for detection of the absolute concentrations of oxy-hemoglobin (HbO) and deoxy-hemoglobin (HbR) from hemodynamic responses using a bundled-optode configuration in functional near-infrared spectroscopy (fNIRS) is proposed. The proposed method is then applied to the identification of two fingers (i.e., little and thumb) during their flexion and extension. This experiment involves a continuous-wave-type dual-wavelength (760 and 830 nm) fNIRS and five healthy male subjects. The active brain locations of two finger movements are identified based on the analysis of the t - and p -values of the averaged HbOs, which are quite distinctive. Our experimental results, furthermore, revealed that the hemodynamic responses of two-finger movements are different: The mean, peak, and time-to-peak of little finger movements are higher than those of thumb movements. It is noteworthy that the developed method can be extended to 3-dimensional fNIRS imaging.