Open AccessBiological Activity of Coumarin Derivatives as Anti-Leishmanial Agents
Author(s) -
Vineetha Mandlik,
Sohan Patil,
Ramanamurthy Bopanna,
Sudipta Basu,
Shailza Singh
Publication year - 2016
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0164585
Subject(s) - coumarin , in vivo , pharmacology , cutaneous leishmaniasis , in silico , in vitro , drug , leishmaniasis , medicine , drug resistance , leishmania , chemistry , immunology , biology , biochemistry , microbiology and biotechnology , organic chemistry , parasite hosting , gene , world wide web , computer science
Cutaneous leishmaniasis affects nearly 0.7 to 1.3 million people annually. Treatment of this disease is difficult due to lack of appropriate medication and the growing problem of drug resistance. Natural compounds such as coumarins serve as complementary therapeutic agents in addition to the current treatment modalities. In this study, we have performed an in-silico screening of the coumarin derivatives and their anti-leishmanial properties has been explored both in-vitro and in-vivo . One of the compounds (compound 2) exhibited leishmanicidal activity and to further study its properties, nanoliposomal formulation of the compound was developed. Treatment of cutaneous lesions in BALB/c mice with compound 2 showed significantly reduced lesion size as compared to the untreated mice (p<0.05) suggesting that compound 2 may possess anti-leishmanial properties.